|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:NR3A1
ERα
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bone
gptkb:endometrial_cancer
|
|
gptkbp:dimerizes_with
|
gptkb:Estrogen_receptor_alpha
gptkb:Estrogen_receptor_beta
|
|
gptkbp:discoveredBy
|
1962
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000091831
|
|
gptkbp:first_cloned
|
1986
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
nuclear receptor
|
|
gptkbp:gene
|
gptkb:ESR1
|
|
gptkbp:GO_term
|
GO:0003707
|
|
gptkbp:HGNC_ID
|
3467
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Estrogen receptor alpha
|
|
gptkbp:ligand
|
estrogen
|
|
gptkbp:locatedOnChromosome
|
6q25.1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:member
|
nuclear receptor family
|
|
gptkbp:member_of_subfamily
|
gptkb:steroid_hormone_receptors
|
|
gptkbp:molecularWeight
|
66 kDa
|
|
gptkbp:OMIM
|
133430
|
|
gptkbp:PDB
|
1A52
3ERT
|
|
gptkbp:phosphorylates
|
Ser118
Ser167
|
|
gptkbp:RefSeq
|
gptkb:NM_000125
|
|
gptkbp:regulates_process
|
cell proliferation
gene expression
reproductive development
|
|
gptkbp:targetOfDrug
|
gptkb:fulvestrant
gptkb:tamoxifen
raloxifene
|
|
gptkbp:tissue_specificity
|
gptkb:breast
gptkb:bone
gptkb:prostate
gptkb:testis
liver
uterus
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:KR-ERB
|
|
gptkbp:bfsLayer
|
7
|