|
gptkbp:instanceOf
|
gptkb:drug
potassium-sparing diuretic
|
|
gptkbp:approvalYear
|
1964
|
|
gptkbp:ATCCode
|
C03DB02
|
|
gptkbp:bioavailability
|
30-70%
|
|
gptkbp:brand
|
Dyrenium
|
|
gptkbp:CASNumber
|
396-01-0
|
|
gptkbp:combines
|
gptkb:hydrochlorothiazide
|
|
gptkbp:contraindication
|
hyperkalemia
severe kidney impairment
anuria
|
|
gptkbp:discoveredBy
|
gptkb:Smith_Kline_&_French
|
|
gptkbp:eliminationHalfLife
|
1-2 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:hasMolecularFormula
|
C12H11N7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
triamterene
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits epithelial sodium channels in the distal nephron
|
|
gptkbp:meltingPoint
|
316-317°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
5546
5347
CHEMBL1531
DB00384
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
kidney stones
hyperkalemia
|
|
gptkbp:synonym
|
2,4,7-triamino-6-phenylpteridine
|
|
gptkbp:UNII
|
G7RT8N6O5E
|
|
gptkbp:usedFor
|
edema
hypertension
|
|
gptkbp:bfsParent
|
gptkb:ENaC
|
|
gptkbp:bfsLayer
|
7
|