CYP2B6

E902894

cytochrome P450 enzyme drug-metabolizing enzyme enzyme protein

CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.

Try in SPARQL Jump to: Surface forms Disambiguation Statements Elicitation Referenced by

All labels observed (3)

Label	Occurrences
CYP2B6 canonical	5
CYP2B6 gene	1
CYP2B6*9 allele	1

How this entity was disambiguated

This entity first appeared as the object of triple T11074513 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.

NED1 Entity disambiguation (via context triple) gpt-5-mini-2025-08-07

Target entity: CYP2B6
Context triple: [cyclophosphamide, isMetabolizedBy, CYP2B6]

A. CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
B. CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
C. CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
D. CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
E. CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
F. None of above. chosen
G. Unsure - the case is ambiguous/there is not enough information to decide.

NED2 Entity disambiguation (via description) gpt-5-mini-2025-08-07

Target entity: CYP2B6
Target entity description: CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.

A. CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
B. CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
C. CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
D. CYP2C9
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
E. CYP2C19
CYP2C19 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs, including certain antidepressants, proton pump inhibitors, and antiplatelet agents.
F. None of above. chosen

Statements (74)

Predicate	Object
instanceOf	cytochrome P450 enzyme ⓘ drug-metabolizing enzyme ⓘ enzyme ⓘ protein ⓘ
associatedWith	altered methadone maintenance dose requirements ⓘ efavirenz-induced central nervous system toxicity ⓘ interindividual variability in drug response ⓘ
cellularComponent	integral component of membrane ⓘ microsome ⓘ
cofactor	heme ⓘ
encodedBy	CYP2B6 gene ⓘ linked to: CYP2B6
expressedIn	brain ⓘ intestine ⓘ kidney ⓘ liver ⓘ lung ⓘ
foundInTaxon	Homo sapiens ⓘ
geneticVariationAffects	bupropion clearance ⓘ cyclophosphamide activation ⓘ efavirenz plasma concentration ⓘ
hasECNumber	1.14.14.1 ⓘ
hasMolecularWeight	approximately 56 kDa ⓘ
inducedBy	St John’s wort ⓘ carbamazepine ⓘ phenobarbital ⓘ phenytoin ⓘ rifampicin ⓘ
inhibitedBy	clopidogrel ⓘ linked to: Plavix clotrimazole ⓘ ketoconazole ⓘ paroxetine ⓘ sertraline ⓘ linked to: Zoloft thioTEPA ⓘ ticlopidine ⓘ
involvedIn	N-demethylation of bupropion ⓘ N-demethylation of methadone ⓘ bioactivation of cyclophosphamide ⓘ bioactivation of ifosfamide ⓘ hydroxylation of efavirenz ⓘ hydroxylation of ketamine ⓘ
locatedIn	endoplasmic reticulum ⓘ
memberOf	CYP2 family ⓘ CYP2B subfamily ⓘ cytochrome P450 superfamily ⓘ
molecularFunction	drug binding ⓘ heme binding ⓘ iron ion binding ⓘ monooxygenase activity ⓘ oxidoreductase activity ⓘ
participatesIn	drug metabolic process ⓘ fatty acid metabolic process ⓘ oxidation-reduction process ⓘ steroid metabolic process ⓘ xenobiotic metabolic process ⓘ
polymorphismIn	CYP2B64 allele ⓘ CYP2B65 allele ⓘ CYP2B66 allele ⓘ CYP2B69 allele ⓘ linked to: CYP2B6
regulatedBy	constitutive androstane receptor ⓘ pregnane X receptor ⓘ
substrateOf	artemisinin ⓘ bupropion ⓘ clopidogrel ⓘ linked to: Plavix cyclophosphamide ⓘ diazepam ⓘ efavirenz ⓘ ifosfamide ⓘ ketamine ⓘ methadone ⓘ linked to: Methadone nevirapine ⓘ propofol ⓘ sertraline ⓘ linked to: Zoloft tamoxifen ⓘ thiotepa ⓘ

How these facts were elicited

Referenced by (7)

Full triples — surface form annotated when it differs from this entity's canonical label.

cyclophosphamide → isMetabolizedBy → CYP2B6 ⓘ

Velpatasvir → metabolizedBy → CYP2B6 ⓘ

subject linked to: velpatasvir

Zoloft → isMetabolizedBy → CYP2B6 ⓘ

Pregnane X receptor → regulatesExpressionOf → CYP2B6 ⓘ

subject linked to: pregnane X receptor

constitutive androstane receptor → upregulatesExpressionOf → CYP2B6 ⓘ

CYP2B6 → encodedBy → CYP2B6 gene ⓘ

linked to: CYP2B6

CYP2B6 → polymorphismIn → CYP2B6*9 allele ⓘ