cytochrome P450 superfamily
E1549311
UNEXPLORED
The cytochrome P450 superfamily is a large and diverse group of heme-containing enzymes that catalyze the oxidation of a wide variety of endogenous compounds and xenobiotics, playing key roles in drug metabolism and biosynthesis of hormones and lipids.
All labels observed (1)
| Label | Occurrences |
|---|---|
| cytochrome P450 superfamily canonical | 4 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690150 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: cytochrome P450 superfamily Context triple: [CYP1A2, memberOf, cytochrome P450 superfamily]
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A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
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B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
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C.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
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D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
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E.
CYP2B6
CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: cytochrome P450 superfamily Target entity description: The cytochrome P450 superfamily is a large and diverse group of heme-containing enzymes that catalyze the oxidation of a wide variety of endogenous compounds and xenobiotics, playing key roles in drug metabolism and biosynthesis of hormones and lipids.
-
A.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
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C.
cytochrome P450 reductase
Cytochrome P450 reductase is a flavoprotein enzyme that transfers electrons from NADPH to cytochrome P450 enzymes, enabling their role in drug metabolism and biosynthesis of endogenous compounds.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
CYP2B6
CYP2B6 is a human liver cytochrome P450 enzyme that plays a key role in the metabolism of various drugs and xenobiotics.
- F. None of above. chosen
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.