CYP2C9
E567200
CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
All labels observed (8)
How this entity was disambiguated
This entity first appeared as the object of triple T6064966 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CYP2C9 Context triple: [Prozac, isMetabolizedBy, CYP2C9]
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CYP2C9 Target entity description: CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
-
A.
CYP2D6
CYP2D6 is a highly polymorphic cytochrome P450 enzyme that plays a major role in the metabolism of many drugs, contributing significantly to interindividual variability in drug response.
-
B.
CYP1A2
CYP1A2 is a liver enzyme of the cytochrome P450 family that plays a key role in the metabolism of various drugs and xenobiotics.
-
C.
CYP3A4
CYP3A4 is a major human liver and intestinal enzyme of the cytochrome P450 family responsible for metabolizing a wide range of drugs and xenobiotics.
-
D.
CYP2J2
CYP2J2 is a human cytochrome P450 enzyme primarily expressed in the heart and other tissues, involved in the metabolism of various drugs and endogenous fatty acids.
-
E.
P-glycoprotein
P-glycoprotein is a membrane-bound efflux transporter protein that pumps various drugs and xenobiotics out of cells, influencing their absorption, distribution, and resistance profiles.
- F. None of above. chosen
Statements (52)
| Predicate | Object |
|---|---|
| instanceOf |
cytochrome P450 enzyme
ⓘ
drug-metabolizing enzyme ⓘ protein-coding gene ⓘ |
| associatedWith | adverse drug reactions when activity is altered ⓘ |
| biologicalProcess |
arachidonic acid metabolism
ⓘ
drug clearance ⓘ oxidation of xenobiotics ⓘ |
| cellularLocation | endoplasmic reticulum ⓘ |
| clinicalRelevance |
pharmacogenomics of anticoagulant therapy
ⓘ
risk of warfarin-induced bleeding ⓘ |
| cofactor | heme ⓘ |
| encodes | cytochrome P450 2C9 protein ⓘ |
| expressedIn | liver ⓘ |
| fullName |
cytochrome P450 family 2 subfamily C member 9
ⓘ
linked to:
CYP2C9
|
| geneID | 1559 ⓘ |
| hasMolecularFunction |
monooxygenase activity
ⓘ
oxidoreductase activity ⓘ |
| hasPolymorphism |
CYP2C9*11
ⓘ
linked to:
CYP2C9
CYP2C9*2 ⓘ
linked to:
CYP2C9
CYP2C9*3 ⓘ
linked to:
CYP2C9
CYP2C9*5 ⓘ
linked to:
CYP2C9
CYP2C9*6 ⓘ
linked to:
CYP2C9
CYP2C9*8 ⓘ
linked to:
CYP2C9
|
| inducedBy |
carbamazepine
ⓘ
rifampin ⓘ |
| inhibitedBy |
amiodarone
ⓘ
fluconazole ⓘ sulfamethoxazole ⓘ |
| locatedIn | chromosome 10q23.33 ⓘ |
| memberOf |
CYP2C subfamily
ⓘ
cytochrome P450 superfamily ⓘ |
| metabolizes |
S-warfarin
ⓘ
celecoxib ⓘ
linked to:
Celebrex
diclofenac ⓘ fluvastatin ⓘ glipizide ⓘ ibuprofen ⓘ losartan ⓘ many NSAIDs ⓘ many oral anticoagulants ⓘ phenytoin ⓘ tolbutamide ⓘ warfarin ⓘ |
| pathway |
drug metabolism
ⓘ
xenobiotic metabolism ⓘ |
| polymorphismsAffect |
enzyme activity
ⓘ
warfarin dose requirements ⓘ |
| regulation | transcriptionally regulated by nuclear receptors ⓘ |
| species | Homo sapiens ⓘ |
| substrateSpecificity | small lipophilic molecules ⓘ |
| uniprotID | P11712 ⓘ |
| usesCofactor | NADPH ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: CYP2C9 Description of subject: CYP2C9 is a liver enzyme of the cytochrome P450 family that plays a key role in metabolizing various drugs, including many nonsteroidal anti-inflammatory agents and anticoagulants.
Referenced by (22)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
H2 receptor antagonist cimetidine
linked to: CYP2C9
linked to: CYP2C9
linked to: CYP2C9
linked to: CYP2C9
linked to: CYP2C9
linked to: CYP2C9
subject linked to:
pregnane X receptor