fluconazole
E561768
Fluconazole is a triazole antifungal medication commonly used to treat and prevent a wide range of Candida infections in humans.
All labels observed (2)
| Label | Occurrences |
|---|---|
| fluconazole canonical | 4 |
| Diflucan | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T6005999 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: fluconazole Context triple: [Candida albicans, isTreatedWith, fluconazole]
-
A.
voriconazole
Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
-
B.
posaconazole
Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
-
C.
amphotericin B
Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
-
D.
Candida
Candida is a comedic play by George Bernard Shaw that explores marriage, love, and social ideals through the story of a clergyman’s wife caught between her husband and a young poet.
-
E.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: fluconazole Target entity description: Fluconazole is a triazole antifungal medication commonly used to treat and prevent a wide range of Candida infections in humans.
-
A.
voriconazole
Voriconazole is a broad-spectrum triazole antifungal medication commonly used to treat serious invasive fungal infections, particularly those caused by Aspergillus species.
-
B.
posaconazole
Posaconazole is a broad-spectrum triazole antifungal medication commonly used to prevent and treat serious invasive fungal infections, particularly in immunocompromised patients.
-
C.
amphotericin B
Amphotericin B is a broad-spectrum antifungal medication primarily used to treat severe, systemic fungal infections.
-
D.
Candida
Candida is a comedic play by George Bernard Shaw that explores marriage, love, and social ideals through the story of a clergyman’s wife caught between her husband and a young poet.
-
E.
Isentress
Isentress is an antiretroviral medication (an HIV integrase inhibitor) used to treat HIV infection in adults and children.
- F. None of above. chosen
Statements (53)
| Predicate | Object |
|---|---|
| instanceOf |
WHO Essential Medicine
ⓘ
azole antifungal ⓘ pharmaceutical drug ⓘ triazole antifungal drug ⓘ |
| activeAgainst |
Candida albicans
ⓘ
Cryptococcus neoformans ⓘ other Candida species (variable susceptibility) ⓘ |
| approvedBy |
U.S. Food and Drug Administration
ⓘ
linked to:
Food and Drug Administration
|
| commonAdverseEffect |
abdominal pain
ⓘ
diarrhea ⓘ headache ⓘ nausea ⓘ |
| crosses | blood–brain barrier ⓘ |
| developedBy | Pfizer ⓘ |
| discoveredIn | 1980s ⓘ |
| eliminatedBy | renal excretion ⓘ |
| eliminationHalfLife | approximately 20–50 hours in adults ⓘ |
| hasATCCode | J02AC01 ⓘ |
| hasBioavailability | high oral bioavailability ⓘ |
| hasBrandName |
Diflucan
ⓘ
linked to:
fluconazole
|
| hasCASNumber | 86386-73-4 ⓘ |
| hasChemicalFormula | C13H12F2N6O ⓘ |
| hasDrugInteraction |
certain benzodiazepines
ⓘ
phenytoin ⓘ some statins ⓘ sulfonylureas ⓘ warfarin ⓘ |
| hasIUPACName | 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol ⓘ |
| hasMechanismOfAction |
inhibits ergosterol synthesis in fungal cell membranes
ⓘ
inhibits fungal cytochrome P450 enzyme 14α-demethylase ⓘ |
| hasMolarMass | 306.27 g/mol ⓘ |
| hasProteinBinding | low to moderate protein binding ⓘ |
| hasRouteOfAdministration |
intravenous
ⓘ
oral ⓘ topical (some formulations) ⓘ |
| inhibitsEnzyme |
CYP2C19
ⓘ
CYP2C9 ⓘ CYP3A4 ⓘ |
| isOn | World Health Organization Model List of Essential Medicines ⓘ |
| isWaterSoluble | yes ⓘ |
| notActiveAgainst |
Mucorales
ⓘ
most Aspergillus species ⓘ |
| pregnancyCategory | Category D in first trimester (US, systemic use) ⓘ |
| seriousAdverseEffect |
QT interval prolongation
ⓘ
hepatotoxicity ⓘ torsades de pointes (rare) ⓘ |
| usedFor |
prophylaxis of fungal infections in immunocompromised patients
ⓘ
treatment of candidemia ⓘ treatment of cryptococcal meningitis ⓘ treatment of esophageal candidiasis ⓘ treatment of oropharyngeal candidiasis ⓘ treatment of systemic Candida infections ⓘ treatment of vulvovaginal candidiasis ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: fluconazole Description of subject: Fluconazole is a triazole antifungal medication commonly used to treat and prevent a wide range of Candida infections in humans.
Referenced by (5)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: fluconazole