|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:E2F-4
gptkb:E2F_transcription_factor_4
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:chromosomeArm
|
gptkb:16q22
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodes
|
Transcription factor E2F4
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000112246
1874
|
|
gptkbp:expressedIn
|
embryonic development
various human tissues
adult life
|
|
gptkbp:function
|
regulation of cell cycle
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GO_term
|
GO:0003700 (DNA-binding transcription factor activity)
GO:0005634 (nucleus)
GO:0007049 (cell cycle)
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3115
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E2F4 gene
|
|
gptkbp:interactsWith
|
gptkb:DP1_protein
p107
p130
Retinoblastoma protein (pRB)
|
|
gptkbp:involvedIn
|
DNA replication
G1/S transition of mitotic cell cycle
|
|
gptkbp:length
|
413 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_16
|
|
gptkbp:memberOf
|
gptkb:E2F_family
|
|
gptkbp:molecularWeight
|
~46 kDa
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
600426
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
E2f4
|
|
gptkbp:RefSeq
|
NM_001950
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
differentiation
DNA repair
activator
repressor
|
|
gptkbp:regulatoryElement
|
enhancer region
promoter region
|
|
gptkbp:significance
|
biomarker for cancer prognosis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
gptkb:Q16254
|
|
gptkbp:bfsParent
|
gptkb:E2F4
|
|
gptkbp:bfsLayer
|
8
|