|
gptkbp:instanceOf
|
gptkb:protein
cell surface receptor
|
|
gptkbp:alternativeName
|
CD62E
ELAM-1
endothelial-leukocyte adhesion molecule 1
|
|
gptkbp:biologicalProcess
|
immune system process
cell-cell adhesion
leukocyte migration
cell adhesion molecule activity
carbohydrate binding
|
|
gptkbp:cellularComponent
|
cell surface
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
EGF-like domain
lectin domain
complement regulatory protein-like domains
|
|
gptkbp:encodedBy
|
SELE gene
|
|
gptkbp:Entrez_Gene_ID
|
6401
|
|
gptkbp:expressedIn
|
activated endothelial cells
|
|
gptkbp:expressedInResponseTo
|
inflammatory cytokines
|
|
gptkbp:foundIn
|
endothelial cells
|
|
gptkbp:function
|
mediates adhesion of leukocytes to endothelium
|
|
gptkbp:HGNC_ID
|
10720
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
E-selectin
|
|
gptkbp:involvedIn
|
inflammation
immune response
|
|
gptkbp:ligand
|
gptkb:PSGL-1
sialyl Lewis X
|
|
gptkbp:locatedOnChromosome
|
1q24.2
|
|
gptkbp:membraneLocation
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
~65 kDa
|
|
gptkbp:notExpressedOn
|
resting endothelial cells
|
|
gptkbp:OMIM
|
131150
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1ESL
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:role
|
atherosclerosis
sepsis
autoimmune diseases
cancer metastasis
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:UniProtID
|
P16581
|
|
gptkbp:upregulatedBy
|
gptkb:IL-1
gptkb:TNF-alpha
|
|
gptkbp:bfsParent
|
gptkb:AP1
|
|
gptkbp:bfsLayer
|
7
|