Dopamine receptor D2 protein in Homo sapiens

URI: https://gptkb.org/entity/Dopamine_receptor_D2_protein_in_Homo_sapiens
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alias dopamine D2 receptor
D2R
DRD2
gptkbp:alternativeSplicing D2L (long) isoform
D2S (short) isoform
gptkbp:associatedWith gptkb:Parkinson's_disease
schizophrenia
gptkbp:biologicalProcess G-protein coupled receptor activity
dopamine binding
regulation of neurotransmitter levels
synaptic transmission, dopaminergic
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:discoveredIn 1988
gptkbp:drugClass dopaminergic receptor
antipsychotic drug target
gptkbp:encodedBy gptkb:DRD2_gene
gptkbp:Entrez_Gene_ID 1813
gptkbp:family gptkb:G_protein-coupled_receptor
gptkbp:function G-protein coupled receptor activity
dopamine receptor activity
gptkbp:HGNC_ID gptkb:HGNC:3024
https://www.w3.org/2000/01/rdf-schema#label Dopamine receptor D2 protein in Homo sapiens
gptkbp:interactsWith gptkb:PPP1R9B
GNAI2
ARRB2
NCS-1
gptkbp:length 443 amino acids (D2L isoform)
gptkbp:locatedOnChromosome 11q23.2
gptkbp:OMIM 126450
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB gptkb:6LUQ
6CM4
gptkbp:postTranslationalModification phosphorylation
glycosylation
gptkbp:RefSeq NP_000786.1
gptkbp:structure 7 transmembrane domains
gptkbp:subfamily D2-like dopamine receptor subfamily
gptkbp:target antipsychotic drugs
dopamine agonists
gptkbp:tissue_specificity gptkb:cancer
gptkb:pituitary_gland
gptkb:kidney
brain
heart
retina
gptkbp:type inhibits adenylyl cyclase via Gi/o proteins
gptkbp:UniProtID P14416
ENSP00000264496
gptkbp:bfsParent gptkb:P21912
gptkbp:bfsLayer 8