|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
addiction
bipolar disorder
schizophrenia
|
|
gptkbp:binds
|
dopamine
|
|
gptkbp:encodedBy
|
gptkb:DRD2_gene
|
|
gptkbp:Entrez_Gene_ID
|
1813
ENSG00000149295
|
|
gptkbp:expressedIn
|
gptkb:striatum
gptkb:pituitary_gland
gptkb:cerebral_cortex
gptkb:spinal_cord
gptkb:nucleus_accumbens
gptkb:olfactory_tubercle
retina
hippocampus
amygdala
hypothalamus
|
|
gptkbp:foundIn
|
gptkb:human
mammals
|
|
gptkbp:function
|
modulation of neurotransmission
neurotransmitter receptor
inhibition of adenylyl cyclase
|
|
gptkbp:hasIsoform
|
D2L (long) isoform
D2S (short) isoform
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:3024
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Dopamine receptor D2
|
|
gptkbp:length
|
443
|
|
gptkbp:ligand
|
gptkb:levodopa
gptkb:chlorpromazine
gptkb:pimozide
gptkb:quinpirole
gptkb:aripiprazole
gptkb:clozapine
gptkb:domperidone
gptkb:haloperidol
gptkb:olanzapine
gptkb:quetiapine
gptkb:risperidone
gptkb:amisulpride
gptkb:brexpiprazole
gptkb:cariprazine
gptkb:iloperidone
gptkb:lurasidone
gptkb:melperone
gptkb:paliperidone
gptkb:sertindole
gptkb:sulpiride
gptkb:metoclopramide
gptkb:thioridazine
apomorphine
bromocriptine
cabergoline
tiapride
fluphenazine
molindone
remoxipride
trifluoperazine
ziprasidone
piribedil
pramipexole
ropinirole
levosulpiride
asenaipine
lisuride
pergolide
|
|
gptkbp:locatedIn
|
central nervous system
|
|
gptkbp:locatedOnChromosome
|
11q23.2
|
|
gptkbp:molecularWeight
|
51 kDa
|
|
gptkbp:OMIM
|
126450
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
gptkb:6LUQ
6CM4
7DFP
6VMS
7JVR
|
|
gptkbp:subspecies
|
dopamine receptor
D2-like receptor
|
|
gptkbp:target
|
antipsychotic drugs
dopamine agonists
dopamine antagonists
|
|
gptkbp:UniProtID
|
P14416
|
|
gptkbp:bfsParent
|
gptkb:D2S_(short_isoform)
gptkb:DRD2_gene
gptkb:P21917
gptkb:P21912
gptkb:P21453
|
|
gptkbp:bfsLayer
|
8
|