|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:actsOn
|
gptkb:gene
|
|
gptkbp:catalyzes
|
transient breakage and rejoining of DNA strands
|
|
gptkbp:discoveredBy
|
gptkb:James_C._Wang
|
|
gptkbp:EC_number
|
5.99.1.2
|
|
gptkbp:encodedBy
|
TOP3A gene
TOP1 gene
TOP1MT gene
TOP2A gene
TOP2B gene
TOP3B gene
|
|
gptkbp:foundIn
|
prokaryotes
eukaryotes
|
|
gptkbp:function
|
alters DNA supercoiling
relieves torsional strain in DNA
|
|
gptkbp:GO_term
|
gptkb:GO:0003916
|
|
gptkbp:hasType
|
gptkb:Type_II_topoisomerase
gptkb:Type_I_topoisomerase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DNA topoisomerase
|
|
gptkbp:inhibitedBy
|
gptkb:camptothecin
gptkb:novobiocin
ciprofloxacin
antineoplastic agent
|
|
gptkbp:involvedIn
|
DNA replication
DNA recombination
DNA transcription
|
|
gptkbp:PDB
|
1ZXM
1A36
1K4T
|
|
gptkbp:presentIn
|
gptkb:Bacteria
humans
fungi
plants
archaea
|
|
gptkbp:regulates
|
gptkb:DNA_topology
|
|
gptkbp:requires
|
cell division
genome stability
chromosome segregation
|
|
gptkbp:subunit
|
TOP1
TOP2A
TOP2B
TOP1MT
TOP3
TOP3B
|
|
gptkbp:target
|
antibiotics
anticancer drugs
|
|
gptkbp:Type_I_topoisomerase
|
cuts one strand of DNA
|
|
gptkbp:Type_II_topoisomerase
|
cuts both strands of DNA
|
|
gptkbp:bfsParent
|
gptkb:CHEBI:15765
|
|
gptkbp:bfsLayer
|
7
|