|
gptkbp:instanceOf
|
gptkb:protein
dopamine receptor
|
|
gptkbp:alternativeName
|
Dopamine receptor D1
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
addiction
schizophrenia
|
|
gptkbp:drugClass
|
D1-like receptor
|
|
gptkbp:encodedBy
|
DRD1 gene
|
|
gptkbp:enemyOf
|
gptkb:SKF-38393
gptkb:ecopipam
dopamine
SCH-23390
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000184845
1812
|
|
gptkbp:expressedIn
|
gptkb:striatum
limbic system
frontal cortex
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
gptkb:G_protein-coupled_receptor
stimulates adenylyl cyclase
|
|
gptkbp:gene
|
gptkb:DRD1
|
|
gptkbp:HGNC_ID
|
HGNC:3022
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
D1R
|
|
gptkbp:improves
|
cAMP levels
|
|
gptkbp:length
|
446 amino acids
|
|
gptkbp:locatedIn
|
central nervous system
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5_(human)
|
|
gptkbp:molecularWeight
|
49 kDa
|
|
gptkbp:neurotransmitter
|
dopamine
|
|
gptkbp:OMIM
|
126449
|
|
gptkbp:orthologIn
|
gptkb:mouse
right
|
|
gptkbp:recipient
|
dopaminergic receptor
|
|
gptkbp:relatedTo
|
gptkb:D5R
D2R
|
|
gptkbp:role
|
cognition
memory
learning
motor control
reward pathways
|
|
gptkbp:structure
|
seven transmembrane domains
|
|
gptkbp:subclassOf
|
gptkb:G_protein-coupled_receptor
gptkb:dopamine_receptor_family
|
|
gptkbp:type
|
gptkb:Gs_protein
|
|
gptkbp:UniProtID
|
gptkb:P21728
|
|
gptkbp:bfsParent
|
gptkb:dopamine_receptor_D1
|
|
gptkbp:bfsLayer
|
7
|