Cyclin-dependent kinase inhibitor 2B

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:gene
gptkbp:alias	gptkb:MTS2 gptkb:INK4B gptkb:p15 gptkb:CDK4I
gptkbp:associatedWith	tumor suppression
gptkbp:discoveredBy	Serrano et al.
gptkbp:discoveredIn	1994
gptkbp:encodes	gptkb:p15INK4b
gptkbp:Entrez_Gene_ID	gptkb:CDKN2B gptkb:ENSG00000147889 1030
gptkbp:expressedIn	various tissues hematopoietic cells epithelial cells
gptkbp:function	cell cycle regulation inhibits cyclin-dependent kinases
gptkbp:HGNC_ID	HGNC:1788
gptkbp:inhibitedBy	gptkb:CDK4 gptkb:CDK6
gptkbp:length	138 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_9 gptkb:9p21
gptkbp:methylationAssociatedWith	cancer progression gene silencing
gptkbp:molecularWeight	13.8 kDa
gptkbp:mutationAssociatedWith	gptkb:leukemia gptkb:cancer gptkb:glioma gptkb:melanoma
gptkbp:OMIM	600431
gptkbp:orthologIn	gptkb:mouse gptkb:right
gptkbp:partOf	gptkb:INK4_family
gptkbp:RefSeq	NM_004936
gptkbp:regulates	apoptosis cell proliferation cellular senescence G1 phase of cell cycle
gptkbp:relatedTo	gptkb:CDKN2A gptkb:CDKN2C
gptkbp:symbol	gptkb:CDKN2B
gptkbp:target	epigenetic regulation microRNAs
gptkbp:UniProtID	P42772
gptkbp:bfsParent	gptkb:p15INK4b gptkb:Cdkn2b gptkb:p15
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	Cyclin-dependent kinase inhibitor 2B