Cyclin-dependent kinase inhibitor 2B

URI: https://gptkb.org/entity/Cyclin-dependent_kinase_inhibitor_2B
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:gene
gptkbp:alias gptkb:MTS2
gptkb:INK4B
gptkb:p15
gptkb:CDK4I
gptkbp:associatedWith tumor suppression
gptkbp:discoveredBy Serrano et al.
gptkbp:discoveredIn 1994
gptkbp:encodes gptkb:p15INK4b
gptkbp:Entrez_Gene_ID gptkb:CDKN2B
gptkb:ENSG00000147889
1030
gptkbp:expressedIn various tissues
hematopoietic cells
epithelial cells
gptkbp:function cell cycle regulation
inhibits cyclin-dependent kinases
gptkbp:HGNC_ID HGNC:1788
https://www.w3.org/2000/01/rdf-schema#label Cyclin-dependent kinase inhibitor 2B
gptkbp:inhibitedBy gptkb:CDK4
gptkb:CDK6
gptkbp:length 138 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_9
gptkb:9p21
gptkbp:methylationAssociatedWith cancer progression
gene silencing
gptkbp:molecularWeight 13.8 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
leukemia
melanoma
glioma
gptkbp:OMIM 600431
gptkbp:orthologIn gptkb:mouse
right
gptkbp:partOf gptkb:INK4_family
gptkbp:RefSeq NM_004936
gptkbp:regulates apoptosis
cell proliferation
cellular senescence
G1 phase of cell cycle
gptkbp:relatedTo gptkb:CDKN2A
gptkb:CDKN2C
gptkbp:symbol gptkb:CDKN2B
gptkbp:target epigenetic regulation
microRNAs
gptkbp:UniProtID P42772
gptkbp:bfsParent gptkb:p15INK4b
gptkb:Cdkn2b
gptkb:p15
gptkbp:bfsLayer 8