Cell division protein kinase 2

URI: https://gptkb.org/entity/Cell_division_protein_kinase_2
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:CDK2
gptkbp:associatedWith gptkb:cancer
gptkbp:biologicalProcess DNA replication
G1/S transition of mitotic cell cycle
gptkbp:discoveredBy 1990s
gptkbp:EC_number 2.7.11.22
gptkbp:enzymeClassification serine/threonine-protein kinase
gptkbp:form complexed with cyclins
gptkbp:function regulation of cell cycle
gptkbp:gene gptkb:CDK2
https://www.w3.org/2000/01/rdf-schema#label Cell division protein kinase 2
gptkbp:inhibitedBy gptkb:roscovitine
gptkb:p21Cip1
gptkb:p27Kip1
gptkbp:locatedOnChromosome chromosome 12q13
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight 33 kDa
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:mouse_Cdk2
gptkb:rat_Cdk2
gptkbp:PDB 1FIN
gptkbp:postTranslationalModification phosphorylation
gptkbp:requires cell proliferation
gptkbp:structure monomer
forms heterodimer with cyclin E or cyclin A
gptkbp:substrate gptkb:Rb_protein
gptkb:p27Kip1
gptkbp:UniProtID P24941
gptkbp:bfsParent gptkb:P34130
gptkbp:bfsLayer 8