Catechol-O-methyltransferase

URI: https://gptkb.org/entity/Catechol-O-methyltransferase
GPTKB entity
Statements (42)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:COMT
gptkbp:alternativeName gptkb:COMT
gptkbp:CASNumber 9000-50-2
gptkbp:cofactor gptkb:S-adenosyl_methionine
gptkbp:discoveredBy gptkb:Julius_Axelrod
gptkbp:discoveredIn 1958
gptkbp:EC_number 2.1.1.6
gptkbp:enzymeClassification transferase
gptkbp:function degradation of dopamine
degradation of epinephrine
degradation of norepinephrine
methylation of catecholamines
gptkbp:gene gptkb:COMT_gene
gptkbp:GO_term GO:0004100
gptkbp:hasPolymorphism Val158Met
https://www.w3.org/2000/01/rdf-schema#label Catechol-O-methyltransferase
gptkbp:inhibitedBy gptkb:entacapone
gptkb:tolcapone
opicapone
gptkbp:locatedOnChromosome gptkb:22q11.21
gptkbp:location gptkb:cell_membrane
gptkb:kidney
brain
liver
red blood cells
cytosol
gptkbp:molecularWeight 24 kDa
gptkbp:OMIM 116790
gptkbp:PDB 3BWM
gptkbp:significance gptkb:Parkinson's_disease
bipolar disorder
schizophrenia
gptkbp:structure monomer
gptkbp:substrate dopamine
norepinephrine
epinephrine
catechol estrogens
gptkbp:type catechol + S-adenosyl-L-methionine → guaiacol + S-adenosyl-L-homocysteine
gptkbp:UniProtID gptkb:P21964
gptkbp:bfsParent gptkb:Dopamine_(in_brain)
gptkbp:bfsLayer 8