|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:activatedBy
|
dimerization
autoproteolysis
|
|
gptkbp:alternativeName
|
ICH-1
NEDD-2
|
|
gptkbp:associatedWith
|
gptkb:cancer
neurodegenerative diseases
|
|
gptkbp:biologicalProcess
|
cysteine-type endopeptidase activity
|
|
gptkbp:cleavage_site
|
Asp-X bond
|
|
gptkbp:discoveredBy
|
1996
|
|
gptkbp:EC_number
|
3.4.22.55
|
|
gptkbp:encodedBy
|
CASP2 gene
|
|
gptkbp:family
|
gptkb:caspase_family
|
|
gptkbp:form
|
heterotetramer
|
|
gptkbp:function
|
apoptosis
cell cycle regulation
|
|
gptkbp:gene
|
CASP2
|
|
gptkbp:GO_term
|
GO:0004197
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Caspase-2
|
|
gptkbp:involves
|
DNA damage response
intrinsic apoptotic signaling pathway
|
|
gptkbp:locatedOnChromosome
|
7q34-q35
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
48 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Casp2
rat Casp2
|
|
gptkbp:PDB
|
1PYO
|
|
gptkbp:regulates
|
phosphorylation
protein-protein interaction
|
|
gptkbp:research_use
|
apoptosis studies
|
|
gptkbp:reviewedBy
|
gptkb:Nature
gptkb:Cell_Death_and_Differentiation
gptkb:Journal_of_Biological_Chemistry
|
|
gptkbp:structure
|
pro-domain
large subunit
small subunit
|
|
gptkbp:subcellularLocation
|
gptkb:Golgi_apparatus
mitochondria
|
|
gptkbp:substrate
|
gptkb:Bid
gptkb:PARP
|
|
gptkbp:UniProtID
|
P42575
|
|
gptkbp:bfsParent
|
gptkb:Caspase
|
|
gptkbp:bfsLayer
|
7
|