|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
calcium/calmodulin
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:arrhythmia
gptkb:autism_spectrum_disorder
|
|
gptkbp:discoveredBy
|
gptkb:Howard_Schulman
|
|
gptkbp:discoveredIn
|
1983
|
|
gptkbp:EC_number
|
2.7.11.17
|
|
gptkbp:encodedBy
|
gptkb:CAMK2D
CAMK2A
CAMK2B
CAMK2G
|
|
gptkbp:foundIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:fullName
|
Calcium/calmodulin-dependent protein kinase II
|
|
gptkbp:function
|
signal transduction
phosphorylation of proteins
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CaMKII
|
|
gptkbp:inhibitedBy
|
gptkb:KN-93
KN-62
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
memory
learning
|
|
gptkbp:locatedOnChromosome
|
human chromosome 10 (CAMK2G)
human chromosome 4 (CAMK2D)
human chromosome 5 (CAMK2A)
human chromosome 7 (CAMK2B)
|
|
gptkbp:molecularWeight
|
50-60 kDa (per subunit)
|
|
gptkbp:oligomerization
|
dodecamer
tetradecamer
|
|
gptkbp:PDB
|
1HKX
|
|
gptkbp:phosphorylates
|
gptkb:CREB
gptkb:phospholamban
gptkb:RyR2
gptkb:synapsin_I
|
|
gptkbp:postTranslationalModification
|
oxidation
autophosphorylation
O-GlcNAcylation
|
|
gptkbp:regulates
|
cardiac contractility
AMPA receptor trafficking
LTP (long-term potentiation)
|
|
gptkbp:structure
|
gptkb:holoenzyme
|
|
gptkbp:subunit
|
gptkb:government_agency
alpha
beta
gamma
|
|
gptkbp:UniProtID
|
Q13554 (beta)
Q13555 (delta)
Q13557 (gamma)
Q9UQM7 (alpha)
|
|
gptkbp:bfsParent
|
gptkb:calmodulin
|
|
gptkbp:bfsLayer
|
7
|