|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
glutamate
|
|
gptkbp:alsoKnownAs
|
gptkb:GRIA4
glutamate receptor 4
|
|
gptkbp:associatedWith
|
gptkb:autism_spectrum_disorder
epilepsy
neurodevelopmental disorders
|
|
gptkbp:component
|
gptkb:AMPA_receptor
|
|
gptkbp:domain
|
transmembrane domain
ligand-binding domain
amino-terminal domain
|
|
gptkbp:encodedBy
|
gptkb:GRIA4_gene
|
|
gptkbp:expressedIn
|
gptkb:cerebellum
gptkb:cortex
brain
hippocampus
|
|
gptkbp:formsComplexWith
|
gptkb:GluA1
gptkb:GluA2
gptkb:GluA3
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
mediates fast synaptic transmission in the central nervous system
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GluA4
|
|
gptkbp:involvedIn
|
gptkb:synaptic_plasticity
learning and memory
|
|
gptkbp:locatedOnChromosome
|
chromosome 11q22.3 (human)
|
|
gptkbp:location
|
postsynaptic membrane
|
|
gptkbp:memberOf
|
AMPA receptor subunit family
|
|
gptkbp:modulatedBy
|
RNA editing
alternative splicing
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
5L1B
|
|
gptkbp:permeableTo
|
K+
Ca2+
Na+
|
|
gptkbp:phosphorylates
|
gptkb:PKC
gptkb:CaMKII
PKA
|
|
gptkbp:recipient
|
ionotropic glutamate receptor
|
|
gptkbp:regulates
|
neuronal excitability
synaptic strength
|
|
gptkbp:structure
|
tetrameric
|
|
gptkbp:UniProtID
|
P48058
|
|
gptkbp:bfsParent
|
gptkb:AMPA_receptor
|
|
gptkbp:bfsLayer
|
7
|