|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:cardiac_muscle_ryanodine_receptor
gptkb:cardiac_ryanodine_receptor
|
|
gptkbp:associatedWith
|
gptkb:arrhythmogenic_right_ventricular_dysplasia
gptkb:catecholaminergic_polymorphic_ventricular_tachycardia
RyR1
RyR3
|
|
gptkbp:biologicalProcess
|
calcium ion transport
excitation-contraction coupling
|
|
gptkbp:cellularComponent
|
sarcoplasmic reticulum membrane
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:EC_number
|
2.7.11.1
|
|
gptkbp:encodedBy
|
gptkb:RYR2_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000198626
|
|
gptkbp:fullName
|
gptkb:Ryanodine_receptor_2
|
|
gptkbp:function
|
calcium release channel
regulation of cardiac muscle contraction
|
|
gptkbp:gene
|
gptkb:RYR2
|
|
gptkbp:HGNC_ID
|
10484
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RyR2
|
|
gptkbp:interactsWith
|
gptkb:CASQ2
gptkb:calmodulin
gptkb:FKBP12.6
TRDN
JPH2
|
|
gptkbp:locatedOnChromosome
|
1q43
|
|
gptkbp:location
|
sarcoplasmic reticulum
|
|
gptkbp:modulatedBy
|
gptkb:ATP
gptkb:calmodulin
gptkb:FKBP12.6
caffeine
phosphorylation
oxidation
ryanodine
Mg2+
Ca2+
nitrosylation
|
|
gptkbp:molecularWeight
|
approximately 565 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:arrhythmia
heart failure
sudden cardiac death
|
|
gptkbp:OMIM
|
180902
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
6JI8
|
|
gptkbp:RefSeq
|
gptkb:NM_001035
|
|
gptkbp:species
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:subunit
|
homotetramer
|
|
gptkbp:tissue_specificity
|
heart
|
|
gptkbp:UniProtID
|
gptkb:Q92736
|
|
gptkbp:bfsParent
|
gptkb:ryanodine_receptor
gptkb:cardiac_muscle_ryanodine_receptor
gptkb:cardiac_ryanodine_receptor
gptkb:CaMKII
|
|
gptkbp:bfsLayer
|
8
|