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gptkbp:instanceOf
|
genome editing technique
|
|
gptkbp:alsoKnownAs
|
gptkb:CRISPRa
|
|
gptkbp:amendedBy
|
transcriptional activity
|
|
gptkbp:basedOn
|
gptkb:CRISPR-Cas9_system
|
|
gptkbp:canBe
|
gptkb:yeast
gptkb:Bacteria
gptkb:Rta_activator_domain
gptkb:VP64_activator_domain
gptkb:p65_activator_domain
plants
mammalian cells
|
|
gptkbp:developedBy
|
2015
|
|
gptkbp:doesNotCut
|
gptkb:gene
|
|
gptkbp:enables
|
high-throughput screening
activation of endogenous genes
multiplex gene activation
|
|
gptkbp:firstDescribed
|
gptkb:Feng_Zhang
gptkb:George_Church
gptkb:Stanley_Qi
|
|
gptkbp:function
|
gene upregulation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRISPR activation
|
|
gptkbp:publishedIn
|
gptkb:Cell_(journal)
|
|
gptkbp:relatedTo
|
gptkb:CRISPR_interference_(CRISPRi)
|
|
gptkbp:requires
|
dCas9 fusion proteins
|
|
gptkbp:target
|
gptkb:guide_RNA
|
|
gptkbp:usedIn
|
cell reprogramming
disease modeling
functional genomics
gene expression studies
|
|
gptkbp:uses
|
gptkb:catalytically_dead_Cas9_(dCas9)
transcriptional activators
|
|
gptkbp:bfsParent
|
gptkb:CRISPR_interference
|
|
gptkbp:bfsLayer
|
6
|