|
gptkbp:instanceOf
|
gptkb:disease
|
|
gptkbp:abbreviation
|
Chronic Myelomonocytic Leukemia
|
|
gptkbp:affects
|
hematopoietic system
|
|
gptkbp:canProgressTo
|
gptkb:acute_myeloid_leukemia
|
|
gptkbp:characterizedBy
|
dysplasia in one or more myeloid lineages
persistent monocytosis
|
|
gptkbp:diagnosedBy
|
blood test
bone marrow biopsy
|
|
gptkbp:diseaseCategory
|
gptkb:myelodysplastic/myeloproliferative_neoplasm
|
|
gptkbp:firstDescribed
|
1976
|
|
gptkbp:fullName
|
Chronic Myelomonocytic Leukemia
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CMML
|
|
gptkbp:ICD-10_code
|
C93.1
|
|
gptkbp:incidence
|
~0.3 per 100,000 per year
|
|
gptkbp:medianAge
|
65-75 years
|
|
gptkbp:mutationAssociatedWith
|
gptkb:CBL
gptkb:KRAS
gptkb:NRAS
gptkb:ASXL1
gptkb:SRSF2
gptkb:TET2
gptkb:RUNX1
|
|
gptkbp:prognosis
|
variable
|
|
gptkbp:relatedTo
|
myelodysplastic syndromes
myeloproliferative neoplasms
|
|
gptkbp:riskFactor
|
older age
genetic mutations
male gender
|
|
gptkbp:subspecies
|
gptkb:CMML-1
gptkb:CMML-2
CMML-0
|
|
gptkbp:symptom
|
fever
fatigue
splenomegaly
weight loss
|
|
gptkbp:treatment
|
gptkb:hydroxyurea
gptkb:allogeneic_stem_cell_transplantation
hypomethylating agents
|
|
gptkbp:WHOClassification
|
gptkb:myelodysplastic/myeloproliferative_neoplasm
|
|
gptkbp:bfsParent
|
gptkb:Christian_Missions_in_Many_Lands
|
|
gptkbp:bfsLayer
|
6
|