Statements (68)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:myelodysplastic_syndromes
gptkb:Oncology |
| gptkbp:code |
gptkb:ten-eleven_translocation_methylcytosine_dioxygenase_2
|
| gptkbp:discovered_by |
gptkb:2010
|
| gptkbp:function |
DNA demethylation
|
| gptkbp:genetic_studies |
somatic mutation
|
| gptkbp:has_role |
cell differentiation
|
| gptkbp:has_variants |
gptkb:TET2_D140_Y
gptkb:TET2_G127_D gptkb:TET2_K111_N gptkb:TET2_Q261_R gptkb:TET2_R140_Q |
| https://www.w3.org/2000/01/rdf-schema#label |
TET2
|
| gptkbp:initiated_by |
tumorigenesis
|
| gptkbp:interacts_with |
gptkb:IDH1
gptkb:IDH2 |
| gptkbp:involved_in |
cancer progression
epigenetic regulation |
| gptkbp:is_associated_with |
gptkb:chronic_myelomonocytic_leukemia
disease progression genomic instability tumor heterogeneity therapeutic efficacy solid tumors therapeutic resistance hypermutation hypomethylation |
| gptkbp:is_expressed_in |
various tissues
cancer stem cells hematopoietic cells normal tissues |
| gptkbp:is_involved_in |
cell cycle regulation
cellular homeostasis cellular metabolism developmental processes metabolic processes DNA repair mechanisms cell signaling pathways cellular aging stem cell maintenance cellular signaling transcriptional regulation cellular repair mechanisms cellular differentiation pathways cellular responses to stress |
| gptkbp:is_linked_to |
immune response
cancer evolution tumor microenvironment treatment resistance epigenetic alterations poor prognosis in AML |
| gptkbp:is_part_of |
epigenetic landscape
cancer genomics gene regulatory networks cancer biology research cancer pathways epigenetic modification pathways |
| gptkbp:is_regulated_by |
transcription factors
|
| gptkbp:is_studied_for |
biomarker potential
therapeutic targeting |
| gptkbp:is_studied_in |
clinical trials
cancer research |
| gptkbp:located_in |
gptkb:human_chromosome_4q24
|
| gptkbp:related_to |
gptkb:TET_family_of_proteins
|
| gptkbp:targets |
therapeutic agents
|
| gptkbp:bfsParent |
gptkb:myelodysplastic_syndromes
|
| gptkbp:bfsLayer |
5
|