|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:associatedWith
|
gptkb:acute_myeloid_leukemia
gptkb:chronic_myelomonocytic_leukemia
myelodysplastic syndromes
|
|
gptkbp:biologicalProcess
|
epigenetic regulation
hematopoiesis
dioxygenase activity
|
|
gptkbp:discoveredBy
|
Iyer et al.
|
|
gptkbp:discoveredIn
|
2009
|
|
gptkbp:encodes
|
TET2 protein
|
|
gptkbp:Entrez_Gene_ID
|
54790
ENSG00000168769
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:fullName
|
Tet methylcytosine dioxygenase 2
|
|
gptkbp:function
|
DNA demethylation
oxidation of 5-methylcytosine to 5-hydroxymethylcytosine
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
GO:0003677
GO:0016706
|
|
gptkbp:HGNC_ID
|
HGNC:29561
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TET2
|
|
gptkbp:locatedOnChromosome
|
chromosome 4q24 (human)
|
|
gptkbp:mutationAssociatedWith
|
loss-of-function
clonal hematopoiesis
increased risk of hematological malignancies
|
|
gptkbp:OMIM
|
612839
|
|
gptkbp:orthologInMouse
|
Tet2
Tet3
|
|
gptkbp:proteinFamily
|
TET family
|
|
gptkbp:relatedTo
|
TET1
TET3
|
|
gptkbp:symbol
|
gptkb:TET2
|
|
gptkbp:UniProtID
|
Q6N021
|
|
gptkbp:bfsParent
|
gptkb:CMML
gptkb:chronic_myelomonocytic_leukemia
|
|
gptkbp:bfsLayer
|
7
|