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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alsoKnownAs
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gptkb:CDK1
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gptkbp:component
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gptkb:nucleus
gptkb:cytoplasm
|
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gptkbp:discoveredIn
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gptkb:yeast
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gptkbp:encodes
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cyclin-dependent kinase 1
|
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000170312
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gptkbp:expressedIn
|
all dividing cells
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gptkbp:firstDescribed
|
1980s
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gptkbp:function
|
cell cycle regulation
protein serine/threonine kinase activity
G2/M transition
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gptkbp:GOProcess
|
cell division
mitotic cell cycle
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gptkbp:HGNC_ID
|
HGNC:1722
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|
https://www.w3.org/2000/01/rdf-schema#label
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CDC2 gene
|
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gptkbp:inhibitedBy
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gptkb:p21
gptkb:p27
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gptkbp:interactsWith
|
gptkb:cyclin_A
gptkb:cyclin_B1
|
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gptkbp:locatedOnChromosome
|
chromosome 10q21.2
|
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gptkbp:mutationAssociatedWith
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gptkb:cancer
|
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gptkbp:OMIM
|
116940
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
Drosophila melanogaster cdc2
Mus musculus Cdk1
Saccharomyces cerevisiae CDC28
Schizosaccharomyces pombe cdc2
|
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gptkbp:pathway
|
DNA damage response
p53 signaling pathway
cell cycle pathway
|
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gptkbp:phosphorylates
|
Tyr15
Thr14
Thr161
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gptkbp:product
|
gptkb:CDK1_protein
|
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gptkbp:regulates
|
phosphorylation
dephosphorylation
cyclin binding
|
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gptkbp:relatedTo
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cell proliferation
tumorigenesis
checkpoint control
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gptkbp:requires
|
meiosis
mitosis
|
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gptkbp:significance
|
potential cancer therapy target
|
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gptkbp:target
|
Wee1 kinase
Cdc25 phosphatase
|
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gptkbp:UniProtID
|
gptkb:P06493
|
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gptkbp:bfsParent
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gptkb:B-Myb
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gptkbp:bfsLayer
|
8
|