|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:gp67
SIGLEC-3
p67
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:acute_myeloid_leukemia
|
|
gptkbp:contains
|
immunoreceptor tyrosine-based inhibitory motifs (ITIMs)
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:encodes
|
CD33 protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CD33
945
ENSG00000105383
|
|
gptkbp:expressedIn
|
myeloid cells
monocytes
granulocytes
myeloid progenitors
|
|
gptkbp:function
|
cell surface receptor involved in cell-cell interactions
inhibitory receptor modulating immune response
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
1659
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CD33 gene
|
|
gptkbp:involvedIn
|
regulation of immune cell signaling
|
|
gptkbp:length
|
364 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
gptkb:19q13.41
|
|
gptkbp:memberOf
|
gptkb:sialic_acid-binding_immunoglobulin-like_lectins_(Siglecs)
|
|
gptkbp:mutationAssociatedWith
|
risk of Alzheimer's disease
|
|
gptkbp:notExpressedOn
|
erythrocytes
lymphocytes
|
|
gptkbp:OMIM
|
159590
|
|
gptkbp:orthologInChicken
|
gptkb:CD33
|
|
gptkbp:orthologInChimpanzee
|
gptkb:CD33
|
|
gptkbp:orthologInCow
|
gptkb:CD33
|
|
gptkbp:orthologInDog
|
gptkb:CD33
|
|
gptkbp:orthologInFrog
|
cd33
|
|
gptkbp:orthologInMouse
|
Cd33
|
|
gptkbp:orthologInZebrafish
|
cd33
|
|
gptkbp:PDB
|
5IHB
|
|
gptkbp:product
|
type I transmembrane protein
|
|
gptkbp:proteinFamily
|
gptkb:immunoglobulin_superfamily
|
|
gptkbp:regulates
|
phagocytosis
cell adhesion
cytokine production
|
|
gptkbp:significance
|
biomarker for AML diagnosis and therapy
|
|
gptkbp:target
|
gptkb:gemtuzumab_ozogamicin
|
|
gptkbp:UniProtID
|
P20138
|
|
gptkbp:bfsParent
|
gptkb:CD33
|
|
gptkbp:bfsLayer
|
7
|