programmed death-ligand 1

URI: https://gptkb.org/entity/programmed_death-ligand_1
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
immune checkpoint protein
gptkbp:alternativeName gptkb:CD274
PD-L1
gptkbp:binds PD-1 receptor
gptkbp:discoveredIn 1999
gptkbp:encodedBy gptkb:CD274_gene
gptkbp:Entrez_Gene_ID 29126
gptkbp:expressedIn immune cells
tumor cells
gptkbp:foundIn humans
other mammals
gptkbp:function inhibits immune response
https://www.w3.org/2000/01/rdf-schema#label programmed death-ligand 1
gptkbp:involvedIn autoimmune disease
infectious disease response
transplant rejection
regulation of T cell activity
gptkbp:locatedOnChromosome chromosome 9p24.1
gptkbp:location cell surface
gptkbp:molecularWeight 33 kDa
gptkbp:orthologIn gptkb:mouse
right
gptkbp:regulates gptkb:interferon_gamma
inflammatory cytokines
gptkbp:role immunotherapy
cancer immune evasion
immune tolerance
chronic infection
pregnancy immune regulation
gptkbp:structureType type I transmembrane protein
gptkbp:target gptkb:durvalumab
gptkb:atezolizumab
gptkb:pembrolizumab
gptkb:nivolumab
gptkb:avelumab
immune checkpoint inhibitors
gptkbp:UniProtID Q9NZQ7
gptkbp:bfsParent gptkb:PD-L1_expression
gptkb:Atezolizumab
gptkbp:bfsLayer 6