|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PC3
Chromobox homolog 8
HPC3
|
|
gptkbp:amendedBy
|
chromatin structure
|
|
gptkbp:associatedWith
|
gptkb:cancer
colorectal cancer
leukemia
prostate cancer
|
|
gptkbp:binds
|
methylated histone H3 (H3K27me3)
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_1_(PRC1)
|
|
gptkbp:domain
|
chromodomain
Pc box
|
|
gptkbp:encodes
|
Chromobox protein homolog 8
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:CBX8
gptkb:ENSG00000124570
57332
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
chromatin modification
transcriptional repression
|
|
gptkbp:HGNC_ID
|
HGNC:1552
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CBX8
|
|
gptkbp:interactsWith
|
gptkb:PHC1
gptkb:PHC2
gptkb:PHC3
gptkb:RING1B
BMI1
|
|
gptkbp:involvedIn
|
epigenetic gene silencing
|
|
gptkbp:length
|
380
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q21
|
|
gptkbp:memberOf
|
gptkb:Polycomb_group_(PcG)_proteins
|
|
gptkbp:molecularWeight
|
42 kDa
|
|
gptkbp:OMIM
|
602771
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
2L11
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
transcription
HOX gene expression
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
Q9HC52
|
|
gptkbp:bfsParent
|
gptkb:CBX_proteins
|
|
gptkbp:bfsLayer
|
8
|