Polycomb group (PcG) proteins

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:amendedBy	gptkb:histone_H3
gptkbp:associatedWith	gptkb:cancer stem cell maintenance
gptkbp:binds	Polycomb response elements (PREs)
gptkbp:catalyzes	histone H3 lysine 27 trimethylation (H3K27me3)
gptkbp:component	gptkb:PRC1 gptkb:PRC2
gptkbp:discoveredIn	gptkb:Drosophila_melanogaster
gptkbp:enemyOf	Trithorax group (TrxG) proteins
gptkbp:firstDescribed	1978
gptkbp:formComplex	gptkb:Polycomb_Repressive_Complex_1_(PRC1) gptkb:Polycomb_Repressive_Complex_2_(PRC2)
gptkbp:foundIn	animals fungi plants
gptkbp:function	epigenetic gene silencing
https://www.w3.org/2000/01/rdf-schema#label	Polycomb group (PcG) proteins
gptkbp:includes	gptkb:Enhancer_of_zeste_(E(z)) gptkb:Extra_sex_combs_(Esc) gptkb:Polycomb_(Pc) gptkb:Polyhomeotic_(Ph) gptkb:Posterior_sex_combs_(Psc) gptkb:Suppressor_of_zeste_12_(Su(z)12)
gptkbp:inhibitedBy	transcription
gptkbp:involvedIn	cell fate determination developmental gene regulation
gptkbp:mechanismOfAction	histone modification chromatin compaction ubiquitination of histone H2A
gptkbp:regulates	gene expression chromatin structure
gptkbp:represses	gptkb:Hox_genes
gptkbp:requires	embryonic development maintenance of cell identity
gptkbp:studiedIn	gptkb:Arabidopsis_thaliana mammals
gptkbp:bfsParent	gptkb:RING1A
gptkbp:bfsLayer	8