Breast cancer type 2 susceptibility protein

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alsoKnownAs	gptkb:BRCA2
gptkbp:associatedWith	gptkb:hereditary_breast_cancer gptkb:melanoma pancreatic cancer prostate cancer hereditary ovarian cancer male breast cancer
gptkbp:discoveredBy	gptkb:Michael_Stratton
gptkbp:discoveredIn	1994
gptkbp:domain	DNA-binding domain helical domain BRC repeats OB-fold domain
gptkbp:encodedBy	gptkb:BRCA2_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000139618 675
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	DNA repair homologous recombination
gptkbp:HGNC_ID	1101
gptkbp:interactsWith	gptkb:PALB2 gptkb:DSS1 gptkb:BRCA1 gptkb:RAD51
gptkbp:length	3418 amino acids
gptkbp:locatedOnChromosome	gptkb:chromosome_13q13.1
gptkbp:molecularWeight	384 kDa
gptkbp:mutationAssociatedWith	germline increased cancer risk somatic
gptkbp:OMIM	600185
gptkbp:orthologIn	gptkb:Bos_taurus gptkb:Danio_rerio gptkb:Mus_musculus gptkb:Pan_troglodytes gptkb:Canis_lupus_familiaris
gptkbp:PDB	1MIU
gptkbp:postTranslationalModification	phosphorylation ubiquitination
gptkbp:RefSeq	NP_000050.2
gptkbp:role	genome stability tumor suppression cell cycle control
gptkbp:subcellularLocation	gptkb:nucleus chromatin
gptkbp:UniProtID	P51587
gptkbp:bfsParent	gptkb:BRCA2
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Breast cancer type 2 susceptibility protein