Breast cancer type 2 susceptibility protein

URI: https://gptkb.org/entity/Breast_cancer_type_2_susceptibility_protein
GPTKB entity
Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:BRCA2
gptkbp:associatedWith gptkb:hereditary_breast_cancer
melanoma
pancreatic cancer
prostate cancer
hereditary ovarian cancer
male breast cancer
gptkbp:discoveredBy gptkb:Michael_Stratton
gptkbp:discoveredIn 1994
gptkbp:domain DNA-binding domain
helical domain
BRC repeats
OB-fold domain
gptkbp:encodedBy gptkb:BRCA2_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000139618
675
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function DNA repair
homologous recombination
gptkbp:HGNC_ID 1101
https://www.w3.org/2000/01/rdf-schema#label Breast cancer type 2 susceptibility protein
gptkbp:interactsWith gptkb:PALB2
gptkb:DSS1
gptkb:BRCA1
gptkb:RAD51
gptkbp:length 3418 amino acids
gptkbp:locatedOnChromosome gptkb:chromosome_13q13.1
gptkbp:molecularWeight 384 kDa
gptkbp:mutationAssociatedWith germline
increased cancer risk
somatic
gptkbp:OMIM 600185
gptkbp:orthologIn gptkb:Bos_taurus
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Pan_troglodytes
gptkb:Canis_lupus_familiaris
gptkbp:PDB 1MIU
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:RefSeq NP_000050.2
gptkbp:role genome stability
tumor suppression
cell cycle control
gptkbp:subcellularLocation gptkb:nucleus
chromatin
gptkbp:UniProtID P51587
gptkbp:bfsParent gptkb:P51532
gptkb:BRCA2
gptkbp:bfsLayer 7