|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Activin receptor type-2B
|
|
gptkbp:associatedWith
|
gptkb:cancer
fibrosis
muscle wasting
|
|
gptkbp:binds
|
gptkb:GDF11
myostatin
activin A
activin B
|
|
gptkbp:encodedBy
|
ACVR2B gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:fullName
|
Activin receptor type IIB
|
|
gptkbp:function
|
serine/threonine kinase receptor
receptor for activins
|
|
gptkbp:gene
|
ACVR2B
|
|
gptkbp:HGNC_ID
|
173
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ActRIIB
|
|
gptkbp:locatedOnChromosome
|
chromosome 3q22
|
|
gptkbp:location
|
gptkb:cell_membrane
|
|
gptkbp:modulatedBy
|
apoptosis
cell differentiation
muscle growth
reproductive system development
|
|
gptkbp:molecularWeight
|
~57 kDa
|
|
gptkbp:mutationAssociatedWith
|
muscle hypertrophy
|
|
gptkbp:OMIM
|
602730
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:pathway
|
gptkb:TGF-beta_signaling_pathway
|
|
gptkbp:PDB
|
2H64
|
|
gptkbp:structure
|
single-pass type I membrane protein
|
|
gptkbp:target
|
therapeutic antibodies
ligand traps
|
|
gptkbp:UniProtID
|
Q13705
|
|
gptkbp:bfsParent
|
gptkb:BMP9
gptkb:Growth_Differentiation_Factor_2
gptkb:growth_differentiation_factor_2
gptkb:Nodal_gene
|
|
gptkbp:bfsLayer
|
7
|