|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ApoA-I
apolipoprotein A1
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
gptkb:Alzheimer's_disease
atherosclerosis
coronary artery disease
high-density lipoprotein
familial hypoalphalipoproteinemia
|
|
gptkbp:biologicalProcess
|
antioxidant activity
activates LCAT
anti-inflammatory activity
binds cholesterol
binds phospholipids
major protein component of HDL
|
|
gptkbp:clinicalTrialPhase
|
HDL cholesterol measurement
|
|
gptkbp:discoveredBy
|
gptkb:Donald_Fredrickson
|
|
gptkbp:encodes
|
gptkb:apolipoprotein_A-I
|
|
gptkbp:Entrez_Gene_ID
|
335
ENSG00000118137
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:function
|
reverse cholesterol transport
cholesterol transport
|
|
gptkbp:HGNC_ID
|
HGNC:600
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APOA1 gene
|
|
gptkbp:length
|
267 amino acids
|
|
gptkbp:locatedOnChromosome
|
11
11q23.3
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Tangier_disease
gptkb:familial_HDL_deficiency
|
|
gptkbp:OMIM
|
107680
|
|
gptkbp:orthologInMouse
|
gptkb:Apoa1
|
|
gptkbp:pathway
|
lipid metabolism
reverse cholesterol transport
cholesterol efflux
|
|
gptkbp:product
|
gptkb:apolipoprotein_A-I
amphipathic alpha-helix
|
|
gptkbp:proteinFamily
|
apolipoprotein family
|
|
gptkbp:regulates
|
cholesterol efflux from cells
plasma HDL levels
|
|
gptkbp:sequence
|
1862 bp
|
|
gptkbp:UniProtID
|
P02647
|
|
gptkbp:variant
|
APOA1 Fin
APOA1 Milano
APOA1 Paris
|
|
gptkbp:bfsParent
|
gptkb:Apolipoprotein_A-I
|
|
gptkbp:bfsLayer
|
7
|