Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:containsGene |
gptkb:APOE
gptkb:APP gptkb:PSEN1 gptkb:PSEN2 gptkb:MAPT |
| gptkbp:foundIn |
gptkb:human
|
| gptkbp:hasBiologicalActivity |
gptkb:beta-secretase
gptkb:gamma-secretase tau kinase |
| https://www.w3.org/2000/01/rdf-schema#label |
Alzheimer disease pathway
|
| gptkbp:involves |
synaptic dysfunction
amyloid-beta formation neuronal death neurofibrillary tangle formation tau protein phosphorylation |
| gptkbp:processor |
inflammation
oxidative stress cell death mitochondrial dysfunction synaptic loss amyloid precursor protein cleavage tau hyperphosphorylation |
| gptkbp:referencedIn |
KEGG: hsa05010
Reactome: R-HSA-5683826 WikiPathways: WP2051 |
| gptkbp:bfsParent |
gptkb:P15172
|
| gptkbp:bfsLayer |
7
|