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gptkbp:instanceOf
|
UniProt accession number
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gptkbp:alternativeName
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gptkb:Amyloid_precursor_protein
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gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
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gptkbp:database
|
gptkb:UniProt
|
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gptkbp:disulfideBond
|
Cys144-Cys155
Cys98-Cys105
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gptkbp:Entrez_Gene_ID
|
351
ENSG00000142192
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gptkbp:expressedIn
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gptkb:Heart
gptkb:Brain
gptkb:Placenta
Liver
Kidney
Thyroid
Muscle
Various tissues
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gptkbp:function
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Involved in neuronal growth and repair
Precursor of amyloid beta peptide
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gptkbp:gene
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gptkb:APP
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gptkbp:GO
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gptkb:GO:0007268
GO:0005515
GO:0007155
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gptkbp:hasIsoform
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gptkb:APP695
gptkb:APP751
gptkb:APP770
|
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gptkbp:HGNC_ID
|
620
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P15172
|
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gptkbp:InterPro
|
IPR002897
|
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gptkbp:isUniProtIDFor
|
gptkb:Amyloid_beta_A4_protein
|
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gptkbp:KEGGID
|
hsa:351
|
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gptkbp:lastAnnotationUpdate
|
2022-02-23
|
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gptkbp:latestReleaseVersion
|
2001-11-01
|
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gptkbp:length
|
770 amino acids
|
|
gptkbp:locatedOnChromosome
|
21
|
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gptkbp:locusType
|
21q21.3
|
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gptkbp:mass
|
87,997 Da
|
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gptkbp:mutationAssociatedWith
|
Associated with familial Alzheimer's disease
|
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gptkbp:name
|
A4_HUMAN
|
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gptkbp:OMIM
|
104760
|
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gptkbp:organism
|
gptkb:Homo_sapiens
|
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gptkbp:orthologIn
|
Mus musculus APP
Pan troglodytes APP
Rattus norvegicus APP
|
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gptkbp:pathway
|
gptkb:Alzheimer_disease_pathway
Amyloid fiber formation
|
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gptkbp:PDB
|
gptkb:1AAP
2LFM
5OQV
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gptkbp:postTranslationalModification
|
Phosphorylation
Ubiquitination
Glycosylation
|
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gptkbp:protein_name
|
gptkb:Amyloid_beta_A4_protein
|
|
gptkbp:proteinFamily
|
PF02177
|
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gptkbp:Reactome
|
R-HSA-977225
|
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gptkbp:RefSeq
|
NP_000475.1
|
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gptkbp:reviewedBy
|
true
|
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gptkbp:sequenceStatus
|
Complete
|
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gptkbp:sequenceVersion
|
4
|
|
gptkbp:signalPeptide
|
1-17
|
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gptkbp:subcellularLocation
|
gptkb:Cell_membrane
gptkb:Golgi_apparatus
gptkb:Endoplasmic_reticulum
Secreted
|
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gptkbp:transmembraneDomains
|
700-723
|
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gptkbp:UniGene
|
gptkb:Hs.654592
|
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gptkbp:bfsParent
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gptkb:MyoD1
|
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gptkbp:bfsLayer
|
6
|