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gptkbp:instanceOf
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UniProt accession number
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gptkbp:alternativeName
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gptkb:APP
gptkb:Amyloid_precursor_protein
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gptkbp:associatedWith
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gptkb:Alzheimer's_disease
Cerebral amyloid angiopathy
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gptkbp:biologicalProcess
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Cell adhesion
Neurite outgrowth
Synaptogenesis
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gptkbp:cleavage
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APP intracellular domain (AICD)
p3 peptide
Amyloid-beta peptide
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gptkbp:database
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gptkb:UniProt
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gptkbp:disulfideBond
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Cys144-Cys155
Cys186-Cys209
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gptkbp:domain
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APP intracellular domain (AICD)
E2 domain
Aβ region
Kunitz-type protease inhibitor domain
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gptkbp:Entrez_Gene_ID
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351
ENSG00000142192
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gptkbp:externalLink
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https://www.uniprot.org/uniprot/P49765
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gptkbp:function
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Involved in the pathogenesis of Alzheimer's disease
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gptkbp:gene
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gptkb:APP
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gptkbp:hasIsoform
|
8
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gptkbp:HGNC_ID
|
620
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https://www.w3.org/2000/01/rdf-schema#label
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P49765
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gptkbp:locatedOnChromosome
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21
21q21.3
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gptkbp:mass
|
87,997 Da
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gptkbp:mutationAssociatedWith
|
Associated with familial Alzheimer's disease
Associated with cerebral amyloid angiopathy
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gptkbp:name
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A4_HUMAN
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gptkbp:OMIM
|
104760
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
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APP_BOVIN
APP_CHICK
APP_MOUSE
APP_RAT
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gptkbp:pathway
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gptkb:Alzheimer_disease_pathway
Amyloid fiber formation
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gptkbp:PDB
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gptkb:1AAP
2LFM
5OQV
2M4J
6SHS
6TI5
7Q4B
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gptkbp:postTranslationalModification
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Phosphorylation
Ubiquitination
Glycosylation
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gptkbp:protein_name
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gptkb:Amyloid_beta_A4_protein
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gptkbp:refersTo
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gptkb:Amyloid_beta_A4_protein
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gptkbp:RefSeq
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NP_000475.1
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gptkbp:reviewedBy
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gptkb:Swiss-Prot
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gptkbp:sequence
|
770
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gptkbp:signalPeptide
|
1-17
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gptkbp:status
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Reviewed
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gptkbp:subcellularLocation
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gptkb:Endosome
gptkb:Nucleus
gptkb:Cell_membrane
gptkb:Cytoplasm
gptkb:Golgi_apparatus
gptkb:Endoplasmic_reticulum
gptkb:Lysosome
Secreted
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gptkbp:tissue_specificity
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Expressed in many tissues, especially brain
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gptkbp:transmembraneDomains
|
700-723
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gptkbp:bfsParent
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gptkb:VEGF-B
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gptkbp:bfsLayer
|
7
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