|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:aggregatesFrom
|
neurotoxic
|
|
gptkbp:alias
|
gptkb:SNCA
gptkb:NACP
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
Lewy body dementia
|
|
gptkbp:component
|
Lewy bodies
|
|
gptkbp:discoveredBy
|
gptkb:Maroteaux_et_al.
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:encodedBy
|
gptkb:SNCA_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
pancreas
|
|
gptkbp:form
|
monomer
fibril
oligomer
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
synaptic vesicle regulation
neurotransmitter release modulation
|
|
gptkbp:HGNC_ID
|
11138
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Alpha-synuclein
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:tau_protein
gptkb:synaptobrevin
phospholipids
|
|
gptkbp:involvedIn
|
gptkb:multiple_system_atrophy
neurodegeneration
synucleinopathies
|
|
gptkbp:length
|
140 amino acids
|
|
gptkbp:locatedIn
|
presynaptic terminals
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4q22.1
|
|
gptkbp:molecularWeight
|
14 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:familial_Parkinson's_disease
|
|
gptkbp:OMIM
|
163890
|
|
gptkbp:pathology
|
protein aggregation
neuronal inclusion
|
|
gptkbp:PDB
|
1XQ8
|
|
gptkbp:postTranslationalModification
|
phosphorylation
truncation
ubiquitination
nitration
|
|
gptkbp:role
|
gptkb:synaptic_plasticity
dopaminergic neuron function
|
|
gptkbp:sequence
|
protein-coding
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
mitochondria
|
|
gptkbp:UniProtID
|
gptkb:P37840
|
|
gptkbp:bfsParent
|
gptkb:D010141
|
|
gptkbp:bfsLayer
|
7
|