Adenomatous polyposis coli protein
GPTKB entity
Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:APC_protein
adenomatous polyposis coli tumor suppressor protein |
| gptkbp:discoveredIn |
1991
|
| gptkbp:domain |
armadillo repeat
basic domain 15-amino acid repeat 20-amino acid repeat SAMP repeat |
| gptkbp:encodedBy |
gptkb:APC_gene
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
tumor suppressor
|
| https://www.w3.org/2000/01/rdf-schema#label |
Adenomatous polyposis coli protein
|
| gptkbp:interactsWith |
gptkb:GSK-3β
gptkb:beta-catenin axin |
| gptkbp:involvedIn |
gptkb:Wnt_signaling_pathway
|
| gptkbp:length |
2843 amino acids
|
| gptkbp:locale |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:locatedOnChromosome |
5q21-q22
|
| gptkbp:molecularWeight |
310 kDa
|
| gptkbp:mutationAssociatedWith |
gptkb:familial_adenomatous_polyposis
colorectal cancer |
| gptkbp:OMIM |
611731
|
| gptkbp:regulates |
apoptosis
cell migration cell cycle cell adhesion microtubule stability |
| gptkbp:UniProtID |
P25054
|
| gptkbp:bfsParent |
gptkb:APC_protein
|
| gptkbp:bfsLayer |
7
|