|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
BMP-11
Bone Morphogenetic Protein 11
|
|
gptkbp:cleavage
|
proprotein convertase
|
|
gptkbp:clinicalTrialPhase
|
studied for aging and muscle regeneration
|
|
gptkbp:discoveredBy
|
Nobuyuki Nakashima
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:downstreamOf
|
SMAD2/3 phosphorylation
|
|
gptkbp:Entrez_Gene_ID
|
10220
ENSG00000135414
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:nervous_system
gptkb:kidney
pancreas
|
|
gptkbp:family
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:fullName
|
Growth Differentiation Factor 11
|
|
gptkbp:function
|
regulation of development
muscle regeneration
skeletal patterning
aging regulation
negative regulation of neurogenesis
|
|
gptkbp:HGNC_ID
|
HGNC:4224
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GDF11
|
|
gptkbp:inhibitedBy
|
gptkb:follistatin
GASP-1
GASP-2
|
|
gptkbp:locatedOnChromosome
|
12
|
|
gptkbp:location
|
12q13.2
|
|
gptkbp:molecularWeight
|
~25 kDa (mature form)
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:OMIM
|
605648
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Gdf11
|
|
gptkbp:PDB
|
6B9Z
|
|
gptkbp:product
|
secreted protein
|
|
gptkbp:recipient
|
Activin type II receptors
|
|
gptkbp:regulates
|
aging
neurogenesis
muscle regeneration
anterior-posterior patterning
|
|
gptkbp:relatedTo
|
gptkb:TGF-beta_signaling_pathway
myostatin
|
|
gptkbp:sequenceSimilarity
|
high with myostatin (GDF8)
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:symbol
|
gptkb:GDF11
|
|
gptkbp:UniProtID
|
O95390
|
|
gptkbp:bfsParent
|
gptkb:TGF-beta_superfamily
|
|
gptkbp:bfsLayer
|
7
|