AMPA-type glutamate receptor

URI: https://gptkb.org/entity/AMPA-type_glutamate_receptor
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf ionotropic glutamate receptor
gptkbp:activatedBy glutamate
gptkbp:alsoKnownAs gptkb:AMPA_receptor
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
gptkbp:component excitatory postsynaptic density
gptkbp:discoveredBy Gregory T. Wenthold
gptkbp:dysregulationAssociatedWith gptkb:autism_spectrum_disorder
epilepsy
schizophrenia
neurodegenerative diseases
gptkbp:encodedBy gptkb:GRIA1
gptkb:GRIA2
gptkb:GRIA3
gptkb:GRIA4
gptkbp:enemyOf gptkb:AMPA
gptkb:CNQX
gptkb:NBQX
gptkbp:firstDescribed 1980s
gptkbp:foundIn central nervous system
gptkbp:function mediates fast synaptic transmission
https://www.w3.org/2000/01/rdf-schema#label AMPA-type glutamate receptor
gptkbp:involvedIn excitatory neurotransmission
gptkbp:locale postsynaptic membrane
gptkbp:modulatedBy phosphorylation
RNA editing
auxiliary proteins
gptkbp:permeableTo K+
Ca2+
Na+
gptkbp:pharmacologicalTargetFor anticonvulsants
antidepressants
nootropic drugs
gptkbp:relatedTo gptkb:NMDA_receptor
gptkb:kainate_receptor
gptkbp:role gptkb:synaptic_plasticity
memory
learning
gptkbp:structure tetramer
gptkbp:subjectOf electrophysiological studies
crystal structure studies
gptkbp:subunit gptkb:GluA1
gptkb:GluA2
gptkb:GluA3
gptkb:GluA4
gptkbp:traffickingRegulatedBy gptkb:TARPs
gptkb:SAP97
gptkb:GRIP
PICK1
gptkbp:bfsParent gptkb:AMPA_receptors
gptkbp:bfsLayer 8