|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:GRIA2
glutamate receptor 2
|
|
gptkbp:alternativeSplicing
|
flip
flop
|
|
gptkbp:amendedBy
|
calcium permeability of AMPA receptors
|
|
gptkbp:domain
|
transmembrane domain
ligand-binding domain
amino-terminal domain
carboxy-terminal domain
|
|
gptkbp:encodedBy
|
gptkb:GRIA2_gene
|
|
gptkbp:Entrez_Gene_ID
|
2891
|
|
gptkbp:expressedIn
|
gptkb:cerebral_cortex
gptkb:cerebellum
brain
hippocampus
|
|
gptkbp:firstDescribed
|
1990
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
glutamate-gated ion channel
mediates fast synaptic transmission in CNS
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GluA2
|
|
gptkbp:interactsWith
|
gptkb:NSF
gptkb:TARPs
GRIP1
PICK1
stargazin
|
|
gptkbp:length
|
883 amino acids
|
|
gptkbp:ligand
|
gptkb:AMPA
glutamate
kainate
|
|
gptkbp:locatedOnChromosome
|
4q32-q33
|
|
gptkbp:location
|
postsynaptic membrane
|
|
gptkbp:memberOf
|
AMPA receptor family
|
|
gptkbp:molecularWeight
|
98 kDa
|
|
gptkbp:mutationAssociatedWith
|
amyotrophic lateral sclerosis
|
|
gptkbp:OMIM
|
138247
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
3KG2
|
|
gptkbp:postTranslationalModification
|
RNA editing at Q/R site
|
|
gptkbp:relatedTo
|
epilepsy
neurodegeneration
excitatory neurotransmission
|
|
gptkbp:requires
|
gptkb:synaptic_plasticity
learning and memory
|
|
gptkbp:RNAEditingSite
|
Q/R site
|
|
gptkbp:structure
|
tetrameric
|
|
gptkbp:subunit
|
gptkb:AMPA_receptor
|
|
gptkbp:UniProtID
|
P42262
|
|
gptkbp:bfsParent
|
gptkb:AMPA_receptor
|
|
gptkbp:bfsLayer
|
7
|