Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatedBy |
gptkb:phosphoinositide_3-kinase_(PI3K)_pathway
|
| gptkbp:alsoKnownAs |
gptkb:AKT_family
|
| gptkbp:domain |
gptkb:pleckstrin_homology_domain
regulatory domain protein kinase domain |
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:diabetes cardiovascular diseases |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
serine/threonine kinase activity
|
| https://www.w3.org/2000/01/rdf-schema#label |
Protein kinase B family
|
| gptkbp:involvedIn |
cell proliferation
cell survival cell growth glucose metabolism apoptosis regulation |
| gptkbp:locatedOnChromosome |
chromosome 1 (AKT3)
chromosome 14 (AKT1) chromosome 19 (AKT2) |
| gptkbp:member |
gptkb:AKT1
gptkb:AKT2 gptkb:AKT3 |
| gptkbp:orthologIn |
gptkb:mouse
gptkb:zebrafish right |
| gptkbp:target |
AKT inhibitors
PI3K inhibitors anticancer drugs |
| gptkbp:bfsParent |
gptkb:AKT_family
|
| gptkbp:bfsLayer |
7
|