|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:MRP2
cMOAT
|
|
gptkbp:associatedWith
|
gptkb:Dubin-Johnson_syndrome
|
|
gptkbp:encodes
|
Multidrug resistance-associated protein 2
|
|
gptkbp:Entrez_Gene_ID
|
1244
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
intestine
|
|
gptkbp:fullName
|
ATP binding cassette subfamily C member 2
|
|
gptkbp:function
|
involved in biliary excretion of organic anions
transports organic anions and drugs across cellular membranes
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:54
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCC2 gene
|
|
gptkbp:length
|
1545 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_10
10q24
|
|
gptkbp:memberOf
|
gptkb:ATP-binding_cassette_(ABC)_transporter_family
|
|
gptkbp:mutationAssociatedWith
|
can cause impaired drug excretion
|
|
gptkbp:OMIM
|
601107
|
|
gptkbp:orthologInMouse
|
Abcc2
|
|
gptkbp:product
|
gptkb:cell_membrane
|
|
gptkbp:proteinFamily
|
MRP family
|
|
gptkbp:publicTransit
|
ABC transporter
|
|
gptkbp:relatedTo
|
drug resistance
pharmacokinetics
multidrug resistance
biliary excretion
hepatic transport
|
|
gptkbp:subfamily
|
gptkb:subfamily_C_(CFTR/MRP)_of_ABC_transporters
|
|
gptkbp:transportation
|
gptkb:leukotriene_C4
gptkb:methotrexate
gptkb:cisplatin
gptkb:vincristine
antibiotics
antiviral drugs
anticancer drugs
antineoplastic agent
bile salts
glutathione conjugates
SN-38 glucuronide
bilirubin glucuronides
conjugated bilirubin
estradiol-17β-glucuronide
|
|
gptkbp:UniProtID
|
O15438
|
|
gptkbp:bfsParent
|
gptkb:Canalicular_multispecific_organic_anion_transporter
|
|
gptkbp:bfsLayer
|
7
|