|
gptkbp:instanceOf
|
antineoplastic agent
pyrimidine analog
|
|
gptkbp:administeredBy
|
topical application
intravenous injection
|
|
gptkbp:ATCCode
|
L01BC02
|
|
gptkbp:brand
|
Adrucil
|
|
gptkbp:CASNumber
|
51-21-8
|
|
gptkbp:chemicalFormula
|
C4H3FN2O2
|
|
gptkbp:contraindication
|
pregnancy
severe bone marrow suppression
|
|
gptkbp:discoveredBy
|
Charles Heidelberger
|
|
gptkbp:discoveredIn
|
1957
|
|
gptkbp:eliminatedIn
|
respiratory
renal
|
|
gptkbp:hasSMILES
|
C1=C(C(=O)NC(=O)N1)F
|
|
gptkbp:hasUNII
|
U3P01618RT
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5-fluorouracil
|
|
gptkbp:includedIn
|
gptkb:WHO_Model_List_of_Essential_Medicines
|
|
gptkbp:IUPACName
|
5-fluoropyrimidine-2,4(1H,3H)-dione
|
|
gptkbp:KEGGID
|
D00128
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits thymidylate synthase
|
|
gptkbp:meltingPoint
|
282°C
|
|
gptkbp:metabolism
|
gptkb:dihydropyrimidine_dehydrogenase
|
|
gptkbp:molecularWeight
|
130.08 g/mol
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:PubChem_CID
|
CHEMBL1433
3385
DB00544
|
|
gptkbp:sideEffect
|
gptkb:hand-foot_syndrome
nausea
vomiting
diarrhea
mucositis
myelosuppression
|
|
gptkbp:usedFor
|
gptkb:cancer
colorectal cancer
pancreatic cancer
gastric cancer
|
|
gptkbp:bfsParent
|
gptkb:Folinic_acid
|
|
gptkbp:bfsLayer
|
6
|