|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:DPD
DHPDH
DPDase
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:tegafur
gptkb:capecitabine
gptkb:5-fluorouracil
dihydropyrimidine dehydrogenase deficiency
dihydropyrimidinuria
fluoropyrimidine toxicity
severe 5-FU toxicity
|
|
gptkbp:chromosomeArm
|
gptkb:1p22
|
|
gptkbp:clinicalTrialPhase
|
pharmacogenetic testing for 5-FU sensitivity
|
|
gptkbp:cofactor
|
gptkb:FMN
gptkb:FAD
NADPH
iron-sulfur cluster
|
|
gptkbp:discoveredBy
|
gptkb:Yoshida_et_al.
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodes
|
dihydropyrimidine dehydrogenase (DPD)
|
|
gptkbp:Entrez_Gene_ID
|
1806
ENSG00000188641
|
|
gptkbp:enzymeCommissionNumber
|
1.3.1.2
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
peripheral blood leukocytes
|
|
gptkbp:fullName
|
gptkb:dihydropyrimidine_dehydrogenase
|
|
gptkbp:function
|
pyrimidine catabolism
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:3017
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
DPYD
|
|
gptkbp:inhibitedBy
|
gptkb:gimeracil
eniluracil
|
|
gptkbp:locatedOnChromosome
|
1
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:mutationAssociatedWith
|
IVS14+1G>A
c.1129-5923C>G
c.1679T>G
c.1905+1G>A
c.2846A>T
increased risk of 5-fluorouracil toxicity
|
|
gptkbp:numberOfExons
|
23
|
|
gptkbp:OMIM
|
612779
|
|
gptkbp:orthologInMouse
|
Dpyd
Dypd
|
|
gptkbp:pathway
|
pyrimidine metabolism
|
|
gptkbp:significance
|
pharmacogenomics of cancer chemotherapy
|
|
gptkbp:substrate
|
gptkb:5-fluorouracil
thymine
uracil
|
|
gptkbp:UniProtID
|
P32322
|
|
gptkbp:bfsParent
|
gptkb:dihydropyrimidine_dehydrogenase
|
|
gptkbp:bfsLayer
|
7
|