Statements (64)
Predicate | Object |
---|---|
gptkbp:instance_of |
gptkb:monoclonal_antibody
|
gptkbp:administered_by |
gptkb:docetaxel
gptkb:paclitaxel gptkb:pertuzumab gptkb:carboplatin intravenous infusion outpatient settings advanced breast cancer early breast cancer recurrent breast cancer HER2-positive esophageal cancer HER2-positive gastric cancer |
gptkbp:approves |
gptkb:1998
gptkb:FDA |
gptkbp:associated_with |
improved survival rates
|
gptkbp:available_on |
biosimilar products
|
gptkbp:can_be_combined_with |
chemotherapy
|
gptkbp:can_cause |
hypersensitivity reactions
|
gptkbp:clinical_trial |
Phase III
|
gptkbp:contraindication |
pregnancy
severe heart failure |
gptkbp:developed_by |
gptkb:Genentech
|
https://www.w3.org/2000/01/rdf-schema#label |
Trastuzumab
|
gptkbp:indication |
gptkb:Oncology
|
gptkbp:initiated_by |
tumor growth
|
gptkbp:interacts_with |
immune system
|
gptkbp:is_associated_with |
reduced recurrence rates
|
gptkbp:is_considered |
targeted therapy
standard of care life-saving therapy |
gptkbp:is_evaluated_by |
clinical trials
safety and efficacy |
gptkbp:is_monitored_by |
cardiac function
|
gptkbp:is_part_of |
combination therapy
cancer treatment guidelines multimodal treatment approach breast cancer treatment protocols HER2-targeted therapy |
gptkbp:is_subject_to |
patent protection
|
gptkbp:is_used_in |
gptkb:guidelines
palliative care research studies clinical practice |
gptkbp:knockouts |
high affinity for HER2
|
gptkbp:lifespan |
approximately 5-8 days
|
gptkbp:marketed_as |
gptkb:Herceptin
|
gptkbp:mechanism_of_action |
inhibits HER2 receptor signaling
|
gptkbp:produced_by |
Chinese hamster ovary cells
|
gptkbp:route_of_administration |
subcutaneous
|
gptkbp:side_effect |
fatigue
nausea diarrhea infusion reactions cardiotoxicity |
gptkbp:suitable_for |
HER2-negative tumors
|
gptkbp:targets |
HER2 protein
|
gptkbp:used_for |
treatment of HER2-positive breast cancer
|
gptkbp:used_in |
adjuvant therapy
neoadjuvant therapy metastatic breast cancer early-stage breast cancer |
gptkbp:weight |
148 k Da
|
gptkbp:bfsParent |
gptkb:EMD_Serono
|
gptkbp:bfsLayer |
5
|