Statements (21)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
conversion of dUMP to dTMP
|
| gptkbp:cofactor |
gptkb:5,10-methylenetetrahydrofolate
|
| gptkbp:EC_number |
2.1.1.45
|
| gptkbp:foundIn |
gptkb:Bacteria
eukaryotes |
| gptkbp:gene |
gptkb:TYMS
|
| gptkbp:gene_location_(human) |
gptkb:chromosome_18p11.32
|
| https://www.w3.org/2000/01/rdf-schema#label |
thymidylate synthetase
|
| gptkbp:inhibitedBy |
gptkb:5-fluorouracil
raltitrexed |
| gptkbp:locatedIn |
cell nucleus
|
| gptkbp:product |
deoxythymidine monophosphate (dTMP)
|
| gptkbp:requires |
DNA synthesis
tetrahydrofolate |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
deoxyuridine monophosphate (dUMP)
|
| gptkbp:target |
anticancer drugs
|
| gptkbp:UniProtID |
P04818
|
| gptkbp:bfsParent |
gptkb:TYMS
|
| gptkbp:bfsLayer |
7
|