dihydropyrimidine dehydrogenase
GPTKB entity
Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:DPD
|
| gptkbp:biologicalProcess |
oxidoreductase activity
|
| gptkbp:catalyzes |
reduction of thymine to dihydrothymine
reduction of uracil to dihydrouracil |
| gptkbp:cofactor |
NADPH
|
| gptkbp:EC_number |
1.3.1.2
|
| gptkbp:function |
pyrimidine catabolism
|
| gptkbp:gene |
gptkb:DPYD
|
| https://www.w3.org/2000/01/rdf-schema#label |
dihydropyrimidine dehydrogenase
|
| gptkbp:locatedOnChromosome |
gptkb:1p22
|
| gptkbp:location |
cytosol
|
| gptkbp:organism |
gptkb:human
mammals |
| gptkbp:pathway |
pyrimidine metabolism
|
| gptkbp:significance |
deficiency increases toxicity of 5-fluorouracil
deficiency causes dihydropyrimidine dehydrogenase deficiency |
| gptkbp:structure |
multisubunit protein
|
| gptkbp:substrate |
thymine
uracil |
| gptkbp:UniProtID |
gptkb:P32321
|
| gptkbp:bfsParent |
gptkb:Uracil
|
| gptkbp:bfsLayer |
6
|