|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alternativeName
|
gptkb:5-hydroxytryptamine_receptor_1B
gptkb:HTR1B
|
|
gptkbp:associatedWith
|
gptkb:depression
anxiety
aggression
migraine
|
|
gptkbp:couplingType
|
Gi/Go protein
|
|
gptkbp:discoveredIn
|
1980s
|
|
gptkbp:drugClass
|
autoreceptor
heteroreceptor
triptan target
|
|
gptkbp:encodedBy
|
gptkb:HTR1B_gene
|
|
gptkbp:enemyOf
|
gptkb:zolmitriptan
sumatriptan
GR 127935
SB-216641
|
|
gptkbp:expressedIn
|
gptkb:basal_ganglia
gptkb:striatum
brain
substantia nigra
hippocampus
frontal cortex
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:function
|
inhibits neurotransmitter release
|
|
gptkbp:HGNC_ID
|
5292
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
5-HT1B receptor
|
|
gptkbp:IUPHAR_ID
|
1
|
|
gptkbp:ligand
|
serotonin
|
|
gptkbp:locatedOnChromosome
|
chromosome 6q13
|
|
gptkbp:location
|
central nervous system
presynaptic neuron
vascular smooth muscle
|
|
gptkbp:modulatedBy
|
dopamine release
GABA release
acetylcholine release
glutamate release
|
|
gptkbp:OMIM
|
182131
|
|
gptkbp:orthologIn
|
mouse Htr1b
rat Htr1b
|
|
gptkbp:PDB
|
4IAR
|
|
gptkbp:structureType
|
seven transmembrane domain protein
|
|
gptkbp:type
|
inhibits adenylate cyclase
|
|
gptkbp:UniProtID
|
P28222
|
|
gptkbp:bfsParent
|
gptkb:triptans
gptkb:5-HT1_receptor
|
|
gptkbp:bfsLayer
|
7
|