type II CRISPR-Cas system

URI: https://gptkb.org/entity/type_II_CRISPR-Cas_system
GPTKB entity
Statements (43)
Predicate Object
gptkbp:instanceOf gptkb:CRISPR-Cas_system
gptkbp:component gptkb:Cas9_endonuclease
single-guide RNA
gptkbp:contains gptkb:Cas9_protein
gptkb:crRNA
gptkb:tracrRNA
gptkbp:discoveredBy gptkb:Emmanuelle_Charpentier
gptkb:Jennifer_Doudna
gptkbp:example gptkb:Streptococcus_pyogenes
gptkb:Streptococcus_thermophilus
gptkbp:firstDescribed 2012
gptkbp:foundIn gptkb:Bacteria
gptkbp:hasApplication gptkb:gene_drive
personalized medicine
synthetic biology
diagnostics
gene therapy
disease modeling
functional genomics
cell line engineering
crop improvement
animal model creation
epigenome editing
transcriptional regulation
antiviral defense
antimicrobial resistance research
https://www.w3.org/2000/01/rdf-schema#label type II CRISPR-Cas system
gptkbp:mechanismOfAction adaptive immunity
DNA interference
gptkbp:providesImmunityAgainst plasmids
bacteriophages
gptkbp:requires gptkb:RNase_III
PAM sequence
host factors
gptkbp:subclassOf gptkb:CRISPR-Cas_system
gptkbp:usedFor genome editing
gene regulation
gene knockout
gptkbp:usedIn gptkb:biotechnology
gptkb:medicine
agriculture
gptkbp:bfsParent gptkb:type_V_CRISPR-Cas_system
gptkbp:bfsLayer 8