trimethoprim-sulfamethoxazole

URI: https://gptkb.org/entity/trimethoprim-sulfamethoxazole
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf antibiotic combination
gptkbp:ATCCode gptkb:J01EE01
gptkbp:availableOn gptkb:tablet
oral suspension
injectable solution
gptkbp:brand gptkb:Co-trimoxazole
gptkb:Bactrim
gptkb:Septra
gptkbp:concerns increasing bacterial resistance
gptkbp:contains trimethoprim
sulfamethoxazole
gptkbp:contraindication severe kidney disease
severe liver disease
sulfa allergy
pregnancy (late term)
gptkbp:discoveredBy 1968
gptkbp:drugClass antibacterial
sulfonamide
gptkbp:eliminationHalfLife 8-14 hours
gptkbp:excretion gptkb:kidney
https://www.w3.org/2000/01/rdf-schema#label trimethoprim-sulfamethoxazole
gptkbp:interactsWith gptkb:phenytoin
gptkb:warfarin
gptkb:spironolactone
gptkb:methotrexate
ACE inhibitors
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction inhibits folic acid synthesis
gptkbp:metabolism liver
gptkbp:pregnancyCategory D (US)
gptkbp:routeOfAdministration oral
intravenous
gptkbp:sideEffect nausea
vomiting
rash
photosensitivity
hyperkalemia
gptkbp:spectrumOfActivity broad spectrum
gptkbp:usedFor gptkb:pneumocystis_pneumonia
gptkb:MRSA_infection
urinary tract infection
shigellosis
traveler's diarrhea
gptkbp:usedIn gptkb:veterinary_medicine
human medicine
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Pneumocystis_pneumonia
gptkbp:bfsLayer 5