tretinoin

URI: https://gptkb.org/entity/tretinoin

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:drug gptkb:vitamin_A
gptkbp:approvedBy	gptkb:FDA 1971
gptkbp:ATCCode	D10AD01
gptkbp:brand	gptkb:Renova gptkb:Retin-A Atralin Avita
gptkbp:CASNumber	302-79-4
gptkbp:category	oncology dermatology
gptkbp:chemicalFormula	C20H28O2
gptkbp:contraindication	pregnancy
gptkbp:discoveredIn	1957
gptkbp:eliminationHalfLife	0.5–2 hours
gptkbp:excretion	urine feces
https://www.w3.org/2000/01/rdf-schema#label	tretinoin
gptkbp:IUPACName	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
gptkbp:legalStatus	prescription only
gptkbp:mechanismOfAction	modulates gene expression promotes cell turnover
gptkbp:meltingPoint	180–182 °C
gptkbp:metabolism	gptkb:vitamin_A liver
gptkbp:molecularWeight	300.44 g/mol
gptkbp:pregnancyCategory	gptkb:X_(US)
gptkbp:prescribes	gptkb:keratosis_pilaris gptkb:melasma leukemia psoriasis hyperpigmentation blackheads stretch marks fine wrinkles
gptkbp:PubChem_CID	444795
gptkbp:routeOfAdministration	oral topical
gptkbp:sideEffect	peeling skin irritation photosensitivity redness
gptkbp:solubility	insoluble in water soluble in organic solvents
gptkbp:synonym	gptkb:all-trans_retinoic_acid
gptkbp:UNII	5688UTC01R
gptkbp:usedFor	gptkb:acute_promyelocytic_leukemia acne photoaging
gptkbp:bfsParent	gptkb:ATRA
gptkbp:bfsLayer	6