Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
TN-C
|
| gptkbp:alternativeSplicing |
multiple isoforms
|
| gptkbp:associatedWith |
gptkb:cancer
asthma rheumatoid arthritis fibrosis |
| gptkbp:discoveredBy |
Ruth Chiquet-Ehrismann
|
| gptkbp:domain |
EGF-like repeats
fibrinogen-like globe fibronectin type III domains |
| gptkbp:encodedBy |
TNC gene
|
| gptkbp:Entrez_Gene_ID |
3371
|
| gptkbp:expressedIn |
tumors
embryonic tissues inflamed tissues |
| gptkbp:firstDescribed |
1986
|
| gptkbp:foundIn |
extracellular matrix
|
| gptkbp:function |
regulates cell migration
extracellular matrix structural constituent involved in cancer progression involved in tissue remodeling involved in wound healing modulates cell adhesion |
| gptkbp:GOProcess |
wound healing
angiogenesis cell adhesion inflammatory response |
| https://www.w3.org/2000/01/rdf-schema#label |
tenascin-C
|
| gptkbp:interactsWith |
gptkb:integrins
gptkb:fibronectin syndecans cell surface receptors |
| gptkbp:locale |
extracellular space
|
| gptkbp:locatedOnChromosome |
9q33
|
| gptkbp:molecularWeight |
~220-300 kDa
|
| gptkbp:OMIM |
187380
|
| gptkbp:PDB |
1TEN
|
| gptkbp:reviewedBy |
gptkb:Journal_of_Cell_Science
gptkb:Nature_Reviews_Cancer |
| gptkbp:significance |
biomarker for inflammation
biomarker for cancer potential therapeutic target |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
hexabrachion (six-armed) structure
|
| gptkbp:UniProtID |
P24821
|
| gptkbp:bfsParent |
gptkb:PTPRZ1
|
| gptkbp:bfsLayer |
7
|